This pattern reflects the multistep hepatocarcinogenesis from dysplastic nodules to overt HCC, where progressive OATP1B3 downregulation in dedifferentiated foci creates differential Gd-EOB-DTPA uptake.[13] The detection of such architectural complexity on HBP may signify early malignant transformation, underscoring its critical role in timely diagnosis. Here, SLCO1B3 is linked to hepatocellular carcinoma.