IFNG and vitiligo: Research has demonstrated that interferon-γ (IFN-γ), secreted by CD8+ T cells, is a critical cytokine that activates the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway, playing a central role in vitiligo pathogenesis.[1] Traditional approaches for vitiligo include topical corticosteroids, phototherapy, and calcineurin inhibitors.