VEGF was initially identified as a multifunctional cytokine in angiogenesis and lymphangiogenesis.[7] In tumor angiogenesis, VEGF promotes the mobilization of inflammatory cells to the tumor site, maintains local inflammatory processes, and induces endothelial cells, platelets, smooth muscle cells, inflammatory cells, fibroblasts, and tumor cells to synthesize pro-angiogenic factors.[8] Tumor associated fibroblasts are the main source of VEGF.[9] Immature cells in the tumor microenvironment secrete more VEGF than mature cells.[10]. Here, VEGFA is linked to neoplasm.