VEGFA and metastatic malignant neoplasm in the lymph nodes: They believed that MVD was associated with deep myometrial invasion, lymph node metastasis, and lower survival rates in endometrial cancer.[15] Another study has found that MVD expression is higher in poorly differentiated endometrial cancers (G2 and G3), and MVD growth coexists with overexpression of VEGF.[6,16] The expression of MVD in endometrial cancer tissue is related to the grading and staging of the tumor.