This high-fat microenvironment is detrimental to follicular development, affecting oocyte maturation and fertilization.[14] At the same time, abnormally high leptin levels in follicular fluid and insulin resistance may interfere with the normal differentiation of ovarian granulosa cells and even inhibit follicular growth and development, leading to premature follicular atresia and apoptosis.[15]. The gene discussed is LEP; the disease is Insulin resistance.