FD is caused by an X-linked mutation of the GLA gene (OMIM #300644; HGNC:4296), which leads to a reduced activity of the lysosomal enzyme α-galactosidase A. This causes accumulation of globotriaosylceramide (Gb3) and its derivative globotriaosylsphingosine (lyso-Gb3) in all tissues [3]. Here, GLA is linked to Fabry disease.