Our histological and immunohistochemical analyses revealed that PFD treatment significantly attenuated ovarian fibrosis in the PCOS model, as demonstrated by reduced collagen deposition on Masson’s trichrome staining and downregulation of key fibrotic markers, including TGF-β1, CTGF, and MMP-9. The gene discussed is CCN2; the disease is polycystic ovary syndrome.