Another example of an integrative approach with regard to genetics in PN is the Food4Me study, incorporating data on both genotype (SNPs Methylenetetrahydrofolate reductase [MTHFR], Fat mass and obesity-associated [FTO], Transcription factor 7-like 2 [TCF7L2], Apolipoprotein E epsilon 4 allele [APOE e4], and FADS1) and phenotype (anthropometrics: weight, BMI, and WC; biomarkers: glucose, TC, carotenes, and n-3 index). This evidence concerns the gene APOE and obesity due to melanocortin 4 receptor deficiency.