Because angptl2 induces both inflammation and cellular senescence, and because inflammation and senescence seem to play a synergistic role in neurodegenerative diseases [27], our aim was to test whether targeting vascular angptl2+ senescent cells would delay the cognitive decline in severely dyslipidemic and spontaneously atherosclerotic LDLR−/−;hApoB100+/+ (ATX) mice. Here, ANGPTL2 is linked to Mental deterioration.