This CCL5 upregulation facilitated immunosuppressive M2-like tumor-associated macrophage (TAM) infiltration in NSCLC via the CCL5/CCR5 axis in intercellular crosstalk between tumor cells and macrophages, a process reversed by blocking CD147-K148me2 with the targeted antibody 12C8. Here, BSG is linked to non-small cell lung carcinoma.