AKT1 and Fanconi anemia: Moreover, the Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis showed that the up-regulated genes were involved in the protein digestion and absorption, cholinergic synapse, and PI3K–Akt signaling pathways (Figure 2—figure supplement 2c, Supplementary file 5); whereas, the down-regulated genes were involved in the cell cycle, progesterone-mediated oocyte maturation, Fanconi anemia, and DNA replication pathways (Figure 2—figure supplement 2d, Supplementary file 6).