Vero and ARPE-19 cells infected with wild-type HSV-1(F), YK801 (Us3-A326V), YK802 (Us3-AV-repair), YK803 (Us3-A326I), or YK804 (Us3-AI-repair) at MOIs of 10 or 0.01 were harvested at various times post-infection, and total virus titers in the infected cells and cell culture supernatants were assayed. The gene discussed is RPS3; the disease is infection.