To investigate whether loss of ERH abolishes ISG induction across species and cell types, we performed 3′ mRNA QuantSeq in IFNγ-treated or non-treated RKO-iCas9 cells (human colon carcinoma) [28] and RAW 264.7-iCas9 cells (murine macrophage) [29]. The gene discussed is ERH; the disease is colon carcinoma.