FGF8 and bacterial infectious disease: In tetrapods, FGF8 is highly expressed in the reproductive and urogenital tracts,[38] and its expression increases during embryonic development and organogenesis.[39, 40] In this study, we found that gcFGF8a is highly expressed in mucosal immune organs in response to bacterial infections and shows elevated expression at skin ulceration sites, suggesting the association of gcFGF8a with bacterial infections.