Low levels of prolactin are identified as a risk factor for the onset and progression of MASLD.[13, 14, 15, 16] Free fatty acids contribute to the development of fatty liver by suppressing prolactin levels.[17] High‐fat diets and social jet lag can disrupt prolactin levels and rhythms, and restoring prolactin levels can help treat fatty liver.[57] The findings indicate that normal prolactin levels and rhythms are essential for metabolic health.[11, 58] In this study, we explored and proposed the use of bionic prolactin supplementation to inhibit the formation of fatty liver. This evidence concerns the gene PRL and metabolic dysfunction-associated steatotic liver disease.