Notably, we observed similar clustering patterns within LCNEC samples from the Rousseaux cohort (Fig. 2G, distribution of INSM1 and SYP expression in Fig. 2F), where expression was quantified using microarray in comparison the RNA-seq based Alcala cohort, underscoring the robust reproducibility of this gene signature in the molecular classification of LCNEC tumors. This evidence concerns the gene SYP and large cell neuroendocrine carcinoma.