Therefore, the targets widely recognized and recommended by scholars at home and abroad were selected to compose a 6-gene test panel for thyroid nodule diagnosis, including BRAF V600E mutation, TERT mutation, and gene fusions (CCDC6-RET, NCOA4-RET, ETV6-NTRK3, EML4-NTRK3, STRN-ALK, and PAX8/PPARG). This evidence concerns the gene CCDC6 and thyroid nodule.