PAX8 and thyroid nodule: Results: Among 826 thyroid nodules, 409 were NGS-positive (49.52%), with a high prevalence of BRAF V600E (36.32%, 300/826) and RAS (9.32%, 77/826) mutations, a low prevalence of TERT promoter mutations (1.69%, 14/826), and gene fusions involving RET (1.82%, 15/826), NTRK3 (0.73%, 6/826), ALK (0.24%, 2/826), and PAX8-PPARG (0.12%, 1/826).