To investigate the role of MPB-Mn3-CB on ECM synthesis, based on the unique microenvironment of intervertebral discs and comparative model evaluations, we adopted an IL1B-induced IDD model to investigate the role of MPB-Mn3-CB in restoring ECM balance (Figure S13) 48-50. The gene discussed is IL1B; the disease is intervertebral disk degenerative disorder.