KRAS and neoplasm: Subsequent flow cytometry analysis of immune cells in the lungs of treated mice revealed that the Kras ASO and immRNA combination treatment led to a remarkable decrease in the number of immunosuppressive cells, including monocytic and granulocytic myeloid-derived suppressor cells (mMDSCs and gMDSCs, respectively) (Figure 5E), while increasing the ratio of M1/M2-like tumor-associated macrophages (Figure 5F) and number of DCs (Figure 5G) in the lung of treated mice.