Flowcytometric analysis of Tie2-CreERT2;Wt1lox/lox+Tamoxifen hearts in the acute phase after infarction revealed on average a nine-fold reduction of MDSC numbers as compared to controls and doubled lymphocyte invasion (including CD3, CD4, and CD8 lymphocytes) (Figure 5). The gene discussed is CD8A; the disease is infarction.