ABCE1 and alkaline phosphatase measurement: Therefore, our future research goals are to explore the role of ABCE1 in mitochondrial damage in pancreatic cells, confirm whether ABCE1 mediates the NMDAR/TRPM4-induced disruption of mitochondrial function during AP, and elucidate the possible molecular signaling pathway through which NMDAR/TRPM4 regulates ABCE1, thereby regulating mitophagy and ultimately affecting mitochondrial function in AP.