Moreover, we propose that the interplay between NMDA receptors and TRPM4 channels may involve both physical interactions mediated by proteins like TwinF (as reported by Yan et al.)and functional coupling, where Ca2+ influx via NMDA receptors directly activates TRPM4 through Ca2+/calmodulin-dependent mechanisms in AP. The gene discussed is TRPM4; the disease is alkaline phosphatase measurement.