The repeated cholangitis group (Group B) exhibited an abundance of progranulin (GRN), ganglioside GM2 activator (GM2A), antileukoproteinase (SLPI), laminin subunit beta-3 (LAMB3), integrin beta-5 (ITGB5), and C-reactive protein (CRP), and lower expression of chloride anion exchanger (SLC26A3), OLA1, unconventional myosin-Ie (MYO1E), ras-related protein Rab-11B (RAB11B), tropomyosin alpha-3 chain (TPM3), and ATP-dependent translocase ABCB1 (ABCB1) (Figure 2B). Here, GRN is linked to cholangitis.