In line with our findings in FGF1 expression, a recent study demonstrated that obesity- and diabetes-induced cardiac dysfunction was accompanied by downregulation of FGF1 expression in the heart, and supplementation of exogenous FGF1 protein could sufficiently prevent obesity- and diabetes-related cardiac dysfunction and damages [35], indicating that cardiac endogenous FGF1 is essential for maintaining myocardial function under metabolic stress conditions. This evidence concerns the gene FGF1 and obesity due to melanocortin 4 receptor deficiency.