FBXW7 mutation with a higher MSI score results in a higher infiltration of M1 macrophage, CD8+ T cell, and regulatory T (Treg) cell and significant enrichment of interleukin (IL)-6 Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) signaling, p53 pathway, and interferon (IFN)-γ and IFN-α response in CRC patients [13]. This evidence concerns the gene IFNG and colorectal carcinoma.