CD44 and neoplasm: As shown in Scheme 1B, first, the negative hyaluronic acid can prolong the circulation time of NPs in vivo and accumulate in the tumor site through the enhanced permeability and retention (EPR) effect, followed by a higher cellular uptake based on the receptor‐ligand action between hyaluronic acid and CD44 which is overexpressed on the cell membrane of TNBC.