Among them, PD‐L1 siRNA (siPD‐L1) can serve as the gene silencing tool to knockdown the expression of PD‐L1 in cancer cells specifically [11], resulting in the enhanced anti‐tumor immune response to kill cancer cells by preventing the interaction between PD‐L1 and PD‐1 on T cells. This evidence concerns the gene CD274 and neoplasm.