During this process, tumor cells secrete immune stimulatory damage‐associated molecular patterns (DAMPs), including surface exposed calreticulinin (CRT), high mobility group box 1 (HMGB1) and adenosine triphosphate (ATP), which activates and promotes the maturation of dendrite cells (DCs) to increase the CD8+ T cells infiltration, finally transforming immune “cold tumors” into “hot tumors”. The gene discussed is HMGB1; the disease is neoplasm.