Histopathology has, furthermore, revealed the localization of NDNF within subepithelial electron-dense deposits, confirming immune complex disease consisting of NDNF and IgG. NDNF decreases and disappears from the serum with successful antibiotic treatment of syphilis and nephrotic syndrome, making it another method of tracking treatment [10]. Here, NDNF is linked to type III hypersensitivity disease.