While vitamin D regulates metabolic processes that have positive long-term health effects, such as enhancing fat metabolism and insulin sensitivity, supplementing vitamin D alone may not reverse obesity, since it is a multifactorial condition [7]. It is crucial to understand the relationship between obesity and vitamin D, since obesity is a chronic condition that affects various diseases, and vitamin D is an important metabolic regulator [3,4,8-10]. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.