In present investigation, Alloxan monohydrate (160 mg/ml per kg BW) induces diabetes which is clearly evidenced by the significant (p < 0.05) decrease in the activities of enzymatic antioxidants like CAT, SOD, and GPx in Group II rabbits (1.5 ± 0.01, 3.2 ± 0.01, 698 ± 1.8 IU/mL, respectively) as compared to Group I rabbits (3.9 ± 0.02, 6.2 ± 0.01, 920 ± 1.7 IU/mL, respectively). The gene discussed is CAT; the disease is diabetes mellitus.