Multiple modules contained genes integral to ECM organization and maintenance, including MMP14, COL6A1, NID1, FN1, THBS1, FBN2, COL8A1, COL3A1, COL11A1, and VCL. 49,50,63,64,71,72,86,87 This suggests astrocyte involvement in restructuring the brain’s extracellular environment in response to AD tau pathology. Here, THBS1 is linked to Alzheimer disease.