SQSTM1 and Alzheimer disease: The tan module contains genes involved in autophagy (SQSTM1),60,61 lysosome function and lipid metabolism (PSAP),62 extracellular matrix remodeling (MMP14 and COL6A1),63,64 growth factors that influence cell growth, differentiation and survival (IGF2)65 whose expression has been noted to decrease in AD patients vs. controls, and which has been touted as a potential therapeutic target.66