The top most significantly enriched in AD brain included proteins involved in RNA processing such as U1 small nuclear ribonucleoprotein 70kDa (U1-70K), known to co-aggregate with AD tau26,27 and various small nuclear ribonucleoprotein-associated proteins, notable because RNA dysregulation may play a role in the progression of AD in some patients.28 Here, SNRNP70 is linked to Alzheimer disease.