The levels of IL-10, ANX-V, and MTHFR in the abortion group were significantly lower than those in the control group (P < 0.001), whereas miR-381-3p knockdown significantly increased the levels of the above three factors, compared with the abortion group (P < 0.01) (Figs. 6C–6E). The gene discussed is MTHFR; the disease is abortion.