In addition to the causes of cardiac uptake without evidence of ATTR or AL amyloidosis mentioned in the introduction, cardiac uptake may also be due to myocardial ischemia, inflammatory myocarditis or pericarditis, hypercalcemia, secondary hyperparathyroidism, prior hydroxychloroquine and Adriamycin administration and radiation therapy (1,3, 13, 14). This evidence concerns the gene TTR and myocardial ischemia.