In addition, Bai et al. [39] showed that BRCA1 depletion stimulates methylation of the GATA3 promoter, thereby repressing GATA3 transcription, and that restoration of GATA3 expression in BRCA1-deficient tumour cells activates mesenchymal-epithelial transition, suppressing tumour initiation and metastasis. This evidence concerns the gene BRCA1 and neoplasm.