On the one hand, we compared DNMT3B+ tumours inducing hypermethylation of the GATA3 promoter region with DNMT3B− tumour samples and, on the other hand, tumours with genetic alteration of GATA3 (LOF mutations or copy number deletions) with the same DNMT3B− tumour samples without LOF mutations or deleterious GATA3 CNAs. This evidence concerns the gene DNMT3B and neoplasm.