ACTA2 and TAGLN encode cytoskeletal proteins that play an important role in fibroblast cell motility and contraction.[74,75]POSTN encodes an extracellular matrix protein associated with cell migration and has been shown to recruit M2 macrophages in ovarian cancer.[76,77] Increased POSTN was observed with fold change log-expression values of 1.23, 3.98, 3.02, and 2.74 and Cohen’s d values of 0.06, 1.36, 1.03, and 1.01 for MSC+M2, OVCAR3+MSC, OVCAR3+MSC+M2, and Cluster 14 compared to MSC-only spheroids, respectively (Fig. 7A). This evidence concerns the gene TAGLN and ovarian cancer.