PDX1 and type 2 diabetes mellitus: There was a higher proportion of nuclear FOXO1, and lower proportion of nuclear PDX1, in PBS-treated, islet donor samples with T2DM than in high BMI samples, whilst OC exposure effected a greater statistical change versus PBS treatment relative to high BMI islet donor samples as well, particularly in the proportional change of nuclear PDX1 (Fig. 5A, D).