In the AF transcriptome, signatures associated with VEGF-A Complex, IL1, and Megakaryocytes in Obesity, Hypokalemic Alkalosis, and Negative Regulation of TORC2 Signaling increased during degeneration, demonstrating several molecular hallmarks of disc degeneration (Fig. 1E, Fig. S1. This evidence concerns the gene VEGFA and obesity due to melanocortin 4 receptor deficiency.