CRTC2 and obesity due to melanocortin 4 receptor deficiency: In the AF transcriptome, signatures associated with VEGF-A Complex, IL1, and Megakaryocytes in Obesity, Hypokalemic Alkalosis, and Negative Regulation of TORC2 Signaling increased during degeneration, demonstrating several molecular hallmarks of disc degeneration (Fig. 1E, Fig. S1.