In the AF transcriptome, signatures associated with VEGF-A Complex, IL1, and Megakaryocytes in Obesity, Hypokalemic Alkalosis, and Negative Regulation of TORC2 Signaling increased during degeneration, demonstrating several molecular hallmarks of disc degeneration (Fig. 1E, Fig. S1. The gene discussed is IL1B; the disease is obesity due to melanocortin 4 receptor deficiency.