PLCG2 and Alzheimer disease: Second, a common SNP upstream of PLCG2, rs12446759, within the LNC adjacent to PLCG2, also reduces AD risk and has unclear actions on PLCG2 (Bellenguez et al., 2022; Dalmasso et al., 2019; Jansen et al., 2019; Kleineidam et al., 2020; Magno et al., 2019; Olive et al., 2020; Sims et al., 2017; Strickland et al., 2020; van der Lee et al., 2019).