While cancer cells are continuously cycling, that the reduced phosphorylation of Artemis via ATM inhibition has little effect on viability and hairpin opening in these B cells points to NHEJ factors like DNA-PKcs and Artemis as being the more critical targets in blocking DNA repair in blood cancer treatments that rely on overloading cells with DSBs. Here, PRKDC is linked to hematopoietic and lymphoid system neoplasm.