CD8A and type 1 diabetes mellitus: Though not significant, it is striking that a similar immune cell burden is already present at the AAb stage regardless of even lower insulitis frequencies (0.6% PH, 0.8% PT) (Fig. 5A/B) and that its relative magnitude closely mirrors the average pancreatic increase of islet-reactive CD8+ T cells in AAb subjects77; considering specific CD8+ T cell frequencies in peripheral blood77, early immune cell recruitment to pancreatic islets may thus be mostly stochastic before enrichment of beta cell-specific CD8+ T cells becomes discernible at T1D onset.