Similarly, in CRC, histone lactylation increases the stability of potassium channel subfamily K member 6 (Kcnk6) in a YTHDF2-dependent manner, enhancing the activity of potassium channels, inducing the activation of the NOD-like receptor thermal protein domain-associated protein 3 (Nlrp3) inflammasome, and eventually driving inflammation-induced carcinogenesis (Yuan et al., 2024). The gene discussed is KCNK6; the disease is colorectal carcinoma.