PML and neoplasm: Histone lactylation can upregulate AlkB homolog 3 (ALKBH3), which in turn suppresses m1A modification of speckled protein 100A (SP100A), weakening the formation of tumor-suppressive promyelocytic leukemia (PML) protein condensates and facilitating the malignant transformation of tumor cells (Gu X. et al., 2024).