TNFSF11 and osteomyelitis: In the osteomyelitis microenvironment, Nrf2 exhibits dual regulatory functions: on one hand, it promotes M2 macrophage polarization to exert anti-inflammatory effects; on the other, it enhances ROS-scavenging enzyme activity to counteract RANKL-induced oxidative stress, thereby inhibiting osteoclast differentiation and facilitating bone repair.