ITGAX and psoriasis: Psoriasis, characterized by chronic inflammation and keratinocyte proliferation, involves intricate autoinflammatory and T-cell-mediated autoimmune responses.33 Autoinflammatory pathways lead to increased infiltration of effectors such as plasmacytoid dendritic cells (pDCs), myeloid dendritic cells (CD11c+ mDCs), neutrophils and natural killer (NK) cells, and antimicrobial peptides (AMPs).34–37 The downstream effects of these increased effectors lead to activated immune pathways, eventually increasing keratinocyte proliferation and sustained inflammation.