Similarly, mapping of vulnerable GABAergic neuron clusters from Mathys, Peng, Boix et al.[20] to our data set showed that SST+/MAFB+ neurons show a trend towards lower proportions in individuals with higher amyloid-beta load and PHFtau tangle density in all three of our population groups, and CUX2/MSR1+ neurons show the same trend in individuals with higher PHFtau tangle density and steeper slope of cognitive decline (Fig. 4B). Here, CUX2 is linked to Mental deterioration.