The reverse mapping of cluster labels from Green et al.[11] also showed that Mic.12 and Mic.13, both of which express GPNMB and are putatively lipid-processing microglial subgroups, were more abundant in individuals at Braak stage 5 or 6, individuals with a clinical diagnosis of Alzheimer’s dementia, and individuals with higher PHFtau tangle density, in all three of our population groups; the same association was found with Oli.7, the analog of ARHGAP24+ oligodendrocytes, and Ast.10, the analog of WIF1+/VAV3+ astrocytes (Fig. 4B). Here, VAV3 is linked to Alzheimer disease.