LAMA2 and Alzheimer disease: By contrast, oligodendrocyte factors 3 (high expression of LAMA2, and enriched for genes associated with synaptic vesicle recycling) and 5 (high expression of RABGEF1 and enriched for cytoskeleton-associated genes) were lower in both cortical regions in individuals with a clinical diagnosis of Alzheimer’s dementia (Fig. 2D,E, S5).