This was particularly the case for oligodendrocytes: oligodendrocyte factor 4 (with high expression of SLC5A3, and enriched in genes associated with immune signaling and lipid processing, Fig. S5) is more prevalent in individuals with higher neuritic plaque counts, higher PHFtau tangle density, and a clinical diagnosis of Alzheimer’s dementia, in both the STG and the AC. Here, SLC5A3 is linked to Alzheimer disease.