Thus, findings like putatively differential chromatin accessibility at the AD-associated locus containing KANSL1 (Fig. 3c), or the lack of cross-population group reproducibility of vulnerable neuronal signatures identified from prior studies (e.g. LAMP5+/RELN+ GABAergic neurons, Fig. 4b, Supplemental Table 1) does not necessarily indicate race- or ethnicity-specific differences, but could rather be due to lack of power in the overall study design. Here, RELN is linked to Alzheimer disease.