INS and Hypoglycemia: The mechanism of hypoglycemia includes anti-insulin antibodies that bind to endogenous insulin and form an insulin-Ab complex; hence insulin cannot reach its receptor in the liver and other peripheral tissues, causing transient hyperglycemia, which stimulates the pancreas to release more insulin, turning this complex unstable as the antibodies lose affinity to insulin and bind off, releasing insulin molecules leading mainly but not exclusively to postprandial hypoglycemia [18].