SNRK and hydrops fetalis: Previously, using a nonischemic Ang II-induced HF mouse model, we showed that SNRK acts as a cardiomyocyte-specific repressor of inflammation and fibrosis.7 When we evaluated fibrosis in a chamber-specific manner in Snrk cmcKO mice using Picrosirius red staining for collagen fibers, we observed a slightly higher fibrosis in the atrial chamber than in the ventricular chamber under both basal and Ang II-infused conditions (P < 0.05, P < 0.01; Figure 1A–E).