The establishment of an ARRGRS consisting of 10 biomarkers (S100A4, ASCC3,EPB41L2,NET1,TEX30,CSPG4, MPO,PDE4A, RASAL3,SHANK1) based on differential genes associated with cytarabine resistance was used to categorize AML patients, which helped to assess the overall survival of these patients and response to cytarabine-based therapy. The gene discussed is S100A4; the disease is acute myeloid leukemia.