SOAT1 and cancer: Supports: in Drosophila in terms of the conservation of genes and signaling pathways, Drosophila shares approximately 75% of the disease-causing genes with humans (Reiter et al., 2001), and cancer-related signaling pathways such as Ras, patched/hedgehog, and JAK/STAT are highly conserved during evolution (Harrison et al., 1995; Oro et al., 1997; Wassarman et al., 1995).