Furthermore, chronic activation of neurohormonal pathways - including angiotensin II, aldosterone, and endothelin - along with systemic inflammation and oxidative stress, fosters myocardial fibrosis through ECM remodeling and endothelial dysfunction (Lopez-Lopez et al., 2021; Li et al., 2022; Bailey and Dhaun, 2024). The gene discussed is AGT; the disease is Myocardial fibrosis.