AKT1 and colorectal carcinoma: Furthermore, p-AKT and p-PI3K was highly expressed in HT-29 cells with hsa_circ_0002238 overexpression, whereas it decreased in LoVo cells with hsa_circ_0002238 knockdown, suggesting that the expression level of hsa_circ_0002238 may be related to the PI3K/AKT signaling pathway and enhance CRC growth.