Tumor metabolite lactate promotes tumor growth by regulating MOESIN lactylation in Treg cells, and the LDH inhibitor GSK2837808A combined with anti-programmed cell death-1 (anti-PD-1) has a stronger anti-tumor effect than by anti-PD-1 alone (Gu et al., 2022). The gene discussed is PDCD1; the disease is neoplasm.