Wang et al. found that lysine residues in MeCP2 were lactylated at high levels in the aortic tissues of exercise-trained mice and that lactylation of MeCP2 K271 attenuated ox-LDL-induced inflammation by inhibiting the MAPK pathway to inhibit atherosclerosis development (Wang Y. et al., 2023). This evidence concerns the gene MECP2 and atherosclerosis.