Ferulic acid, a biologically active component of Dangui, exerts a regulatory effect on propylthiouracil-induced hypothyroidism in rats by reducing IL-6 levels, inhibiting inflammatory cascade reactions, improving thyroid function (increasing T3 and T4 while decreasing TSH), and modulating lipid metabolism (levels of total cholesterol, triglycerides, high-density lipoprotein/low-density lipoprotein). This evidence concerns the gene IL6 and hypothyroidism.