Simultaneously, evidence suggests that the water extract of Gleditsia Spina can significantly inhibit tumor size in prostate cancer (PC-3 cell xenografts) (Ryu et al., 2016), block the AGE-RAGE signaling pathway, and induce apoptosis in pancreatic cancer cells (Duan et al., 2023). Here, RENBP is linked to familial pancreatic carcinoma.