↑ Apoptosis, SHP-1 expression↓ Invasive potential of HCC cells, cell proliferation, constitutive/inducible STAT3 activation, STAT3 nuclear accumulation, its DNA binding activity in HCC cells, activity of JAK1, JAK2, and Src, Bcl-2, Bcl-xL, cyclin D1, survivin, VEGF, COX-2, MMP-9. This evidence concerns the gene PTGS2 and hepatocellular carcinoma.